Poor/In depth Metabolizers, CYP2D6 The development from the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Approximately 7% of the population has diminished exercise of your CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme system. These folks are “bad metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, between other medications. https://keikof419gmq4.wikistatement.com/user