Inside the LSD-bound crystal framework, the aspect chain of your lid residue L209EL2 kinds extensive hydrophobic contacts with both of those LSD and surrounding residues in TMs III, IV, and V (Figure 4C). Once the lid moved aside to expose the binding pocket in simulation, several of these contacts broke. https://jaidengdplw.blog-ezine.com/35245557/lsd-crystal-for-dummies