From the LSD-bound crystal framework, the facet chain from the lid residue L209EL2 sorts extensive hydrophobic contacts with both LSD and encompassing residues in TMs III, IV, and V (Figure 4C). Once the lid moved apart to show the binding pocket in simulation, quite a few of those contacts broke. https://jasperomlfz.bloggosite.com/42124817/business-plug-5-meo-copyright-cartridge-and-battery-5ml-deadhead-chemist-an-overview