One of the more widespread signs of peripheral artery disease is claudication, a combination of pains, aches, and cramps while in the troubled limbs. Other signs and symptoms contain: When this happens, the legs are unable to get the necessary nutrients and oxygen which they require, normally resulting in discomfort. https://sgvasculargrp.com/medical-condition/peripheral-arterial-disease/icon-peripheral-arterial-disease-pad-2/