Take note that under these conditions there is often pain either without any stimulus or with a really Light, non-tissue-damaging stimulus. It can be crucial to indicate that (1) there may be pain without having action in Principal afferent nociceptors, and (2) there might be action in Major afferent https://www.proleviate.com/post/conolidine-blocks-ackr3-pain-receptors-in-what-way