Cobicistat will improve the degree or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Acute enhancement or exacerbation of congestive heart failure and new onset of diminished remaining ventricular ejection portion have occurred nifedipine will raise the amount or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 https://heinzb332pbm6.wikimidpoint.com/user